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the drug; and the CNS mechanisms by which the drug produces its effects on behavior. The euphoria and strong reinforcing properties of amphetamines are due to increased dopamine activity in the mesolimbic system. Dependence exists when a person must continue taking a drug in order to function normally and avoid the symptoms of withdrawal (physiological changes associated with the cessation of the drug). Chronic tolerance to nicotine in humans and its relationship to tobacco dependence. The liver metabolizes about 90 percent of the nicotine in the bloodstream before excretion. When inhaled, cocaine is rapidly absorbed by capillaries in the lungs, whereas snorted cocaine hydrochloride is absorbed more slowly into mucous membranes. For example, drugs are categorized according to their chemical structure (e.g., amphetamines whether they are legal or illegal (e.g., caffeine and nicotine. Drugs in and of themselves are not evil, but every drug can be misused and abused. Combined use of opiates and depressants can be particularly hazardous. High-dose cocaine use can cause cocaine-induced psychosis characterized by extreme agitation and anxiety; exaggerated compulsive motor behaviors; delusions of paranoia and persecution; visual, auditory and tactile hallucinations; loss of touch with reality; and permanent brain damage.
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The positively rewarding feelings associated with intravenously injected amphetamine, especially methamphetamine, leads to overwhelming psychological dependence. Thus, physiological dependence does occur thesis span-by-span bridges bridges for many, and most experience craving for marijuana when they stop using the drug. Likewise, when the same dose of drug has less and less of an effect with repeated administrations, tolerance has occurred. Poor reaction time, decreased attention to peripheral visual stimuli, difficulty concentrating, and impairment of complex motor tasks under the influence of marijuana hinders driving ability. Long-term chronic use of methamphetamines is particular neurotoxic, leading to irreversible brain damage and psychosis. THC is an anandamide agonist that, when bound to cannabinoid receptors, inhibits the release of other neurotransmitters at those synapses, especially gaba. Heroin, which is three times more potent than morphine, metabolizes to monoacetylmorphine, which then converts to morphine.
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